Based on our particular expertise in the field of endocrine control of the reproduction of fish, GOBIO has isolated and characterized a pluripotent stem cell line from the brain of a carp. In terms of gene expression, these cells correspond to embryonic stem cells of mammals or induced pluripotent stem cells.
![](https://www.gobio-gmbh.de/wp-content/uploads/2017/05/innovation-gobio-002.jpg)
We assume that longevity, regeneration and seasonal reconstruction of the gonads of carp are based on this cell type. Thus, we have a highly innovative model to investigate stem cell biology in vertebrates.
The cell line was transformed into a transgenic variant with stable histone 2B-associated GFP expression (KCBGFP DSM ACC 3285 Budapest Treaty) in association with the University Hospital of Cologne (Prof. Hescheler / PD Dr. Kurt Pfannkuche). The stable constitutive heritable nuclear labeling of the cells in combination with the pluripotency state opens new perspectives in stem cell / cancer research and in vitro toxicology.